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The 88-year-old pontiff, who remains conscious, received 鈥渉igh flows鈥� of oxygen to help him breathe. He also received blood transfusions after tests showed low counts of platelets, which are needed for clotting, the Vatican said in a late update.

鈥淭he Holy Father鈥檚 condition continues to be critical, therefore, as explained yesterday (Friday), the pope is not out of danger,鈥� the statement said. It was the first time 鈥渃ritical鈥� was used in a written statement to describe Francis' condition since he was hospitalized Feb. 14.

The statement also said the pontiff 鈥渃ontinues to be alert and spent the day in an armchair although in more pain than yesterday." Doctors declined to offer a prognosis, saying it was 鈥渞eserved.鈥�

Doctors warn of the possible onset of sepsis

Doctors have said Francis' condition is touch-and-go, given his age, fragility and pre-existing lung disease.

They warned that the main threat facing Francis would be the聽, a serious infection of the blood that can occur as a complication of pneumonia. As of Friday, there was no evidence of sepsis, and Francis was responding to the various drugs he is taking, the pope鈥檚 medical team said in their first in-depth update on the pope鈥檚 condition.

Saturday's blood tests showed that he developed a low platelet count, a condition called platelopenia or thrombocytopenia. Platelets are cell-like fragments that circulate in the blood that help form blood clots to stop bleeding or help wounds heal. Low platelet counts can be caused by a number of things, including side effects from medicines or infections, according to the U.S. National Institutes of Health.

Francis, who has chronic lung disease and is prone to bronchitis in winter, was admitted to Gemelli hospital Feb. 14 after a聽.

Doctors first diagnosed the聽聽and then the onset of pneumonia in both lungs. They prescribed 鈥渁bsolute rest鈥� and a combination of cortisone and antibiotics, along with supplemental oxygen when he needs it.

Saturday's update marked the first time the Vatican referred to Francis suffering an 鈥渁sthmatic respiratory crisis of prolonged magnitude, which also required the application of oxygen at high flows.鈥�

Dr. Sergio Alfieri, the head of medicine and surgery at Rome鈥檚 Gemelli hospital, said Friday the biggest threat facing Francis was that some of the germs that in his respiratory system may pass into the bloodstream, causing sepsis. That can lead to organ failure and death.

鈥淪epsis, with his respiratory problems and his age, would be really difficult to get out of,鈥� Alfieri told a news conference Friday at Gemelli. 鈥淭he English say 鈥榢nock on wood,鈥� we say 鈥榯ouch iron.鈥� Everyone touch what they want,鈥� he said as he tapped the microphone. 鈥淏ut this is the real risk in these cases: that these germs pass to the bloodstream.鈥�

鈥淗e knows he's in danger,鈥� Alfieri added. 鈥淎nd he told us to convey that.鈥�

Vatican hierarchy tamps down speculation Francis might resign

Meanwhile, the Vatican hierarchy went on the defensive to tamp down rumors and speculation that Francis might decide to resign.

There is no provision in canon law for what to do if a pope becomes incapacitated. Francis previously said he wrote a letter of resignation that would be invoked if he were medically incapable of making such a decision.

The pope remains fully conscious, alert, eating and working.

The Vatican secretary of state, Cardinal Pietro Parolin, gave a rare interview to Corriere della Sera to respond to speculation and rumors about a possible resignation.

It came after the Vatican issued an unusual and official denial of an Italian media report that said Parolin and the pope鈥檚 chief canonist visited Francis in the hospital in secret. Given the canonical requirements to make a resignation legitimate, the implications of such a meeting were significant, but the Vatican denied such a meeting occurred.

Parolin said such speculation seemed 鈥渦seless鈥� when what really mattered was the health of Francis, his recovery and return to the Vatican.

鈥淥n the other hand, I think it is quite normal that in these situations uncontrolled rumors can spread or some misplaced comment is uttered. It is certainly not the first time it has happened,鈥� Parolin was quoted as saying. 鈥淗owever, I don鈥檛 think there is any particular movement, and so far I haven鈥檛 heard anything like that.鈥�

White House is 鈥榩raying for the pope鈥�

White House press secretary Karoline Leavitt said Saturday that President Donald Trump was briefed on the pope鈥檚 condition and was working on his own statement that will be released later.

鈥淲e鈥檙e praying for the pope,鈥� Leavitt said.

Deacons, meanwhile, gathered at the Vatican for their special Holy Year weekend.

Francis got sick at the start of the聽, the once-every-quarter-century celebration of Catholicism. This weekend, he was supposed to have celebrated deacons, a ministry in the church that precedes ordination to the priesthood.

In his place, the Holy Year organizer will celebrate Sunday鈥檚 Mass, the Vatican said. For the second consecutive weekend, Francis will skip his traditional Sunday noon blessing, which he could have delivered from Gemelli if he were up to it.

鈥淟ook, even though he's not (physically) here, we know he's here,鈥� said Luis Arnaldo L贸pez Quirindongo, a deacon from Ponce, Puerto Rico, who was at the Vatican on Saturday for the Jubilee celebration. 鈥淗e's recovering, but he's in our hearts and is accompanying us, because our prayers and his go together.鈥�